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For research use only. Not for human or veterinary use. Not a drug, food, or dietary supplement.
AMIRAVOResearch Library
Cycle-length evidence

NAD+ cycle length: what human studies ran

Not approved — research use onlyBLimited human data
Short answer: there is no established NAD+ cycle length or break. The human studies below ran for set periods under monitoring; none tested repeated courses.

Treatment and follow-up in human studies

  1. The published human study of NAD+ itself used a single 6-hour infusion, with plasma and urine sampling during the infusion and afterwards 10.

What has not been tested

  • On-and-off schedules or breaks between courses.
  • Repeated courses and long-term exposure beyond the periods listed.
  • NAD+ combined with other compounds, unless a study above says so.

Frequently asked questions

Is there an established NAD+ cycle length?
No. Human studies administered NAD+ for the periods listed on this page. Those are study durations; none tested an on-and-off schedule or a break.
What is the longest human study of NAD+?
The durations are listed on this page with their sources; compare them directly rather than relying on a summary.
Do study durations tell me how long to use something?
No. A study duration is how long investigators administered a compound to selected participants under monitoring. It is not a recommended course, and a break between courses has not been tested for any compound on this site that is not approved.
NAD+ dosing reference Full research page

References

  1. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial GeroScience. 2023
  2. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women Science. 2021
  3. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD(+) Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures Cell Reports. 2019
  4. NAD(+) homeostasis in health and disease Nature Metabolism. 2020
  5. NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence Ageing Research Reviews. 2026
  6. NAD (CID 5892) computed properties; Drugs@FDA and openFDA label queries for nicotinamide adenine dinucleotide (no match) PubChem / openFDA. 2026
  7. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the FD&C Act (updated May 14, 2026) FDA. 2026
  8. Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial Nature Aging. 2024
  9. World Anti-Doping Code International Standard: Prohibited List 2026 WADA. 2026
  10. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Front Aging Neurosci. 2019
  11. Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine Front Aging. 2026