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Attribute
Apelin-13
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CategoryHormonal
Evidence gradeB Limited human data
Regulatory statusNot approved — research use only
Human amountsNone establishedDosing reference Study durations
Format
TypeSingle compound
Molecular formulaC69H111N23O16S
Molecular weight1,550.8 g/mol
CAS number217082-58-1
SequenceGln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe (QRPRLSHKGPMPF); the (Pyr1) form carries an N-terminal pyroglutamate in place of the N-terminal glutamine
References15
SummaryApelin-13 is a 13-residue fragment of the endogenous apelin peptide and an agonist at the APJ (apelin) receptor; short randomized human infusion studies report vasodilatation, increased cardiac output and an insulin-sensitising effect, while most disease-level evidence is from cells and rodents and no approved use exists.
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