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Attribute
IGF-1 LR3
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CategoryMuscle
Evidence gradeC Preclinical research
Regulatory statusNot approved — research use only
Human amountsNone establishedDosing reference Study durations
FormatLyophilized vial
TypeSingle compound
Molecular formulaNot listed
Molecular weightNot listed
CAS numberNot listed
SequenceN-terminal 13-residue extension (the first 11 amino acids of methionyl porcine growth hormone followed by Val-Asn) fused to human IGF-I with Arg substituted for Glu at position 3 ([Met1]-pGH(1-11)-Val-Asn-[Arg3]-IGF-I)
References9
SummaryIGF-1 LR3 (Long R3 IGF-I) is a recombinant analogue of human insulin-like growth factor I with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, designed as a laboratory reagent that binds poorly to IGF-binding proteins. It has been studied in cell culture and animals, but no published human administration study was identified. It is not approved for human use, is distinct from the FDA-approved drug mecasermin, and is prohibited in sport; this entry is for research reference only.
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