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Attribute	Tesofensine Get updates
Category	Metabolic
Evidence grade	B Limited human data
Regulatory status	Investigational
Human amounts	Trial dosesDosing reference Study durations
Format	Lyophilized vial
Type	Single compound
Molecular formula	C₁₇H₂₃Cl₂NO
Molecular weight	328.3 g/mol
CAS number	195875-84-4
Sequence	Not listed
References	13
Summary	Tesofensine is an investigational small-molecule inhibitor of noradrenaline, dopamine and serotonin reuptake, not a peptide, originally developed for Parkinson's and Alzheimer's disease and then studied for obesity. A 24-week phase 2 obesity trial reported dose-related body-weight change with increases in heart rate, and that trial report later received an expression of concern from The Lancet. It is not FDA-approved and is named as a prohibited stimulant by WADA; this entry is for research reference only.