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For research use only. Not for human or veterinary use. Not a drug, food, or dietary supplement.
AMIRAVOResearch Library
Cycle-length evidence

L-Glutathione cycle length: what human studies ran

Not approved — research use onlyBLimited human data
Short answer: there is no established L-Glutathione cycle length or break. The human studies below ran for set periods under monitoring; none tested repeated courses.

Treatment and follow-up in human studies

  1. The oral supplementation trial ran 6 months with measurements at 1, 3 and 6 months and a 1-month washout 1; the sublingual crossover used 21-day periods 2.
  2. The intravenous Parkinson's disease pilot administered study medication over 4 weeks and followed participants for a further 8 weeks 3.
  3. The oral skin-lightening study treated for 4 weeks 10; the inhaled cystic fibrosis trial treated for 6 months 12, and the earlier aerosol study for 14 days 13.

What has not been tested

  • On-and-off schedules or breaks between courses.
  • Repeated courses and long-term exposure beyond the periods listed.
  • L-Glutathione combined with other compounds, unless a study above says so.

Frequently asked questions

Is there an established L-Glutathione cycle length?
No. Human studies administered L-Glutathione for the periods listed on this page. Those are study durations; none tested an on-and-off schedule or a break.
What is the longest human study of L-Glutathione?
The durations are listed on this page with their sources; compare them directly rather than relying on a summary.
Do study durations tell me how long to use something?
No. A study duration is how long investigators administered a compound to selected participants under monitoring. It is not a recommended course, and a break between courses has not been tested for any compound on this site that is not approved.
L-Glutathione dosing reference Full research page

References

  1. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione European Journal of Nutrition. 2015
  2. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study Redox Biology. 2015
  3. Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease Movement Disorders. 2009
  4. Glutathione as a skin-lightening agent and in melasma: a systematic review International Journal of Dermatology. 2025
  5. Mechanisms and regulations of ferroptosis Frontiers in Immunology. 2023
  6. A review of the potential benefits and limitations of oral glutathione supplementation Inflammopharmacology. 2026
  7. Drugs@FDA and openFDA NDC directory queries for glutathione (NDA018469 BSS PLUS; NDA020079 discontinued; NDC unapproved homeopathic and OTC monograph entries) openFDA. 2026
  8. Glutathione (CID 124886) computed properties PubChem. 2026
  9. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the FD&C Act (updated May 14, 2026) FDA. 2026
  10. Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study Journal of Dermatological Treatment. 2012
  11. World Anti-Doping Code International Standard: Prohibited List 2026 WADA. 2026
  12. Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial Am J Respir Crit Care Med. 2013
  13. Improvement of alveolar glutathione and lung function but not oxidative state in cystic fibrosis Am J Respir Crit Care Med. 2004