Skip to content
For research use only. Not for human or veterinary use. Not a drug, food, or dietary supplement.
AMIRAVOResearch Library
Cycle-length evidence

PE-22-28 cycle length: what human studies ran

Not approved — research use onlyCPreclinical research
Short answer: there is no established PE-22-28 cycle length, and we found no human studies that report one.

Treatment and follow-up in human studies

No human study durations are recorded.

What has not been tested

  • On-and-off schedules or breaks between courses.
  • Repeated courses and long-term exposure beyond the periods listed.
  • PE-22-28 combined with other compounds, unless a study above says so.

Frequently asked questions

Is there an established PE-22-28 cycle length?
No. We found no human studies that report a treatment duration for PE-22-28.
What is the longest human study of PE-22-28?
None is recorded.
Do study durations tell me how long to use something?
No. A study duration is how long investigators administered a compound to selected participants under monitoring. It is not a recommended course, and a break between courses has not been tested for any compound on this site that is not approved.
PE-22-28 dosing reference Full research page

References

  1. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design PLoS Biology. 2010
  2. A human TREK-1/HEK cell line: a highly efficient screening tool for drug development in neurological diseases PLoS ONE. 2011
  3. Retroinverso analogs of spadin display increased antidepressant effects Psychopharmacology. 2015
  4. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity Frontiers in Pharmacology. 2017
  5. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin Pharmacology & Therapeutics. 2019
  6. The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in Neuronal Excitability Frontiers in Pharmacology. 2019
  7. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides Neuropharmacology. 2019
  8. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin Journal of Diabetes Research. 2016
  9. TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling European Neuropsychopharmacology. 2015
  10. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act (updated May 14, 2026) FDA. 2026
  11. ClinicalTrials.gov search for registered studies of spadin, mini-spadin or PE-22-28 (no records identified) ClinicalTrials.gov. 2026
  12. World Anti-Doping Code International Standard Prohibited List 2026 WADA. 2026