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Attribute
Setmelanotide
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CategoryMetabolic
Evidence gradeA Human trial evidence
Regulatory statusFDA-approved
Human amountsFDA labelDosing reference Study durations
Format
TypeSingle compound
Molecular formulaC49H68N18O9S2
Molecular weight1,117.3 g/mol
CAS number920014-72-8
SequenceAc-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2 (disulfide Cys2-Cys8)
References7
SummarySetmelanotide is a cyclic eight-residue melanocortin-4 receptor agonist that the FDA approved in 2020 as Imcivree for obesity caused by specific genetic MC4R-pathway disorders, with acquired hypothalamic obesity added to the label by 2026.
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