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For research use only. Not for human or veterinary use. Not a drug, food, or dietary supplement.
AMIRAVOResearch Library
Growth Hormone Axis · Dosing reference

Hexarelin dosage

What the human evidence does and does not show, how long studies ran, and the arithmetic for working with vials.

Not approved — research use onlyBLimited human dataNone established
Full research pageCycle-length evidenceComparePrefer Amiravo on Google
Regulatory status
Not approved — research use only
Human amounts
None established in humans
Route studied
—
Frequency
Not established
Half-life
Not established
Evidence grade
Grade B · Limited human data
Vial sizes on the market
2 mg · 5 mg
Other forms seen
—

What Hexarelin is

A synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, studied in endocrine and cardiovascular research models.

Hexarelin binds and activates the growth hormone secretagogue receptor (GHS-R), the same receptor used by the endogenous peptide ghrelin, which is how it raises pituitary growth hormone output 3,5. Beyond growth hormone GHS-R is also expressed in heart and blood vessels, and a review of hexarelin's cardiovascular actions describes the non-GHS-R scavenger receptor CD36 as a specific cardiac receptor for hexarelin… How it works →

Key evidence

  • Arvat et al., J Clin Endocrinol Metab · 2001 · Humans (7 healthy young men)
    Hexarelin raised growth hormone, prolactin, ACTH and cortisol; its growth hormone response was smaller than ghrelin's and larger than GHRH's, and it did not modify the response to ghrelin when given together. 5
  • Imazio et al., Eur J Heart Fail · 2002 · Humans (8 dilated and 5 ischaemic cardiomyopathy patients, with normal and growth-hormone-deficient comparison groups)
    Ejection fraction rose in the ischaemic cardiomyopathy group, as in normal subjects, but not in the dilated cardiomyopathy group, despite a similar growth hormone rise in both. 6
  • Broglio et al., Eur J Pharmacol · 2002 · Humans (24 men with coronary artery disease during bypass surgery)
    Hexarelin increased ejection fraction, cardiac index and cardiac output and reduced wedge pressure; GHRH, recombinant growth hormone and placebo produced no haemodynamic effect, indicating the effect was not mediated by circulating growth hormone. 7
All studies on the research page

What the human evidence shows

No approved or established human dose

We searched PubMed and ClinicalTrials.gov and found no human studies that administered Hexarelin. The research described on its page is from cells or animals, and animal amounts do not translate to people.

How long did human studies run?

No human study durations are recorded for Hexarelin.

Cycle-length evidence for Hexarelin

Side effects reported in studies

  • No side effect reported
    0 reported · 14 healthy elderly subjects given intermittent intranasal or oral courses 8
  • Stimulation of ACTH and cortisol alongside growth hormone
    Observed in the study group · 7 healthy young men given intravenous hexarelin 5
  • No change in heart rate or systemic vascular resistance index during acute administration
    No change versus placebo · 24 men with coronary artery disease during bypass surgery 7
Full adverse-event data

Hexarelin draw calculator

Pick the vial strength and the water added, enter an amount, and see the concentration, the units to draw and how many draws the vial holds. Arithmetic only.

1 · Vial strength
sizes on the market
2 · Water added
3 · Amount per draw
4 · Syringe
Your mix
5 mg + 2 mL water = 2.5 mg/mL
10 units holds 0.25 mg (250 mcg)
Draw toEnter an amount in step 3
0102030405060708090100
U-100 syringe · 100 units = 1 mL

Computed from your inputs. Not a dose or a recommendation.

Compare water volumes for this vialShow

More water = lower concentration = a larger, easier-to-measure draw. Tap a row to use it.

Watermg/mLDraw
0.5 mL10—
1 mL5—
1.5 mL3.333—
2 mL2.5—
2.5 mL2—
3 mL1.667—
5 mL1—

Supplies and handling

  • Lyophilized vial
    Sealed vial with the freeze-dried cake. Check the label, lot and the certificate of analysis before opening.
  • Sterile diluent
    The diluent named on the product documentation. Bacteriostatic water contains benzyl alcohol; sterile water does not.
  • Graduated syringes
    Sized to the volume being measured. U-100 insulin syringes are graduated in units where 100 units = 1 mL.
  • Alcohol prep pads
    For wiping vial stoppers before each puncture.
  • Nitrile gloves
    Clean gloves for aseptic handling.
  • Sharps container
    Puncture-resistant container for used needles.
Step-by-step reconstitution guideStorage and transport accessories

Storage

General research-context handling only. Lyophilised peptide is normally kept cold, dry and shielded from light, with reconstituted solution treated as substantially less stable than the dry powder and repeated freeze-thaw avoided. Defer to the storage temperature, retest date and solvent guidance in the supplier's documentation for the specific lot; no preparation or handling instructions are given here.

  • Lyophilized (unmixed) vials: typically stored cold and dry, away from light, as the documentation directs. Many are stable longer frozen.
  • Reconstituted vials: typically refrigerated (about 2–8 °C), protected from light and not frozen.
  • Bacteriostatic water contains benzyl alcohol, which inhibits bacterial growth in multi-use vials; sterile water has no preservative.

Handling mistakes and troubleshooting

Added the wrong volume of diluent
The concentration changes, not the amount of compound in the vial. Recalculate with the volume actually added and relabel the vial.
Shook the vial and it foamed
Let it settle in the refrigerator. Foam is a sign of agitation; some peptides aggregate when shaken. Note it on the label.
The solution is cloudy or has particles
Do not use it. Cloudiness can indicate incomplete dissolution, contamination or degradation. Record the lot and contact the supplier with the certificate of analysis.
The powder cake looks melted or shrunken before reconstitution
This can indicate the vial was exposed to heat or moisture. Record the lot and condition on arrival.
Liquid sprayed back when the needle was removed
Pressure built up in the vial. Withdraw a small volume of air while adding diluent to keep pressure neutral.

Regulatory status

Status
Hexarelin has no approved drug application in the United States; Drugs@FDA / openFDA searches for both "hexarelin" and "examorelin" return no records 1. It is named in the WADA 2026 Prohibited List, section S2.2.4 2.
United States (FDA)
Not approved. Drugs@FDA / openFDA queries for "hexarelin" and "examorelin" return no matching applications 1. No DailyMed human prescribing information corresponds to an approved hexarelin product.
Sport (WADA)
Prohibited at all times. Section S2.2.4, "Growth hormone releasing factors, including, but not limited to:", names "examorelin (hexarelin)" among the growth hormone-releasing peptides (GHRPs) 2. Class S2 substances are prohibited in- and out-of-competition and are non-Specified.

Status varies by country and changes over time. How we describe regulatory status.

Hexarelin compared with related compounds

CompoundStatusEvidenceHuman amountsHalf-life
HexarelinNot approved — research use onlyBNone established—
GHRP-6Not approved — research use onlyBNone established—
CJC-1295 (no DAC)Not approved — research use onlyCNone establishedNo half-life data specific to the no-DAC
CJC-1295 (with DAC)Not approved — research use onlyBNone establishedEstimated half-life of 5.8 to 8.1 days a
IpamorelinNot approved — research use onlyBNone establishedTerminal half-life of about 2 hours in h
SermorelinNot approved — research use onlyBNone established—

Frequently asked questions

What doses of Hexarelin have been studied in humans?
None that establish an amount. Hexarelin is not approved anywhere and we found no human studies that administered it. Amiravo does not publish community or vendor figures.
Is there an established Hexarelin cycle length?
No. We found no human studies that report treatment duration for Hexarelin.
How much bacteriostatic water should be added to a Hexarelin vial?
There is no compound-specific volume. The diluent volume only sets the concentration: concentration = mass in the vial ÷ volume added (for example, 10 mg in 2 mL gives 5 mg/mL). The calculator on this page shows the arithmetic for any combination.
How many units is a given amount on an insulin syringe?
On a U-100 syringe, 100 units = 1 mL. Units for an amount = amount ÷ (concentration per unit). The calculator converts any amount you enter at the concentration you choose; a unit is a volume mark, not an amount of compound.
Is Hexarelin FDA-approved?
Not approved — research use only. Hexarelin has no approved drug application in the United States; Drugs@FDA / openFDA searches for both "hexarelin" and "examorelin" return no records 1. It is named in the WADA 2026 Prohibited List, section S2.2.4 2.

References

  1. Drugs@FDA application data queried through openFDA for hexarelin and examorelin (no matching application record returned on 22 October 2026) openFDA / Drugs@FDA. 2026
  2. International Standard: Prohibited List 2026 World Anti-Doping Agency. 2026
  3. The cardiovascular action of hexarelin J Geriatr Cardiol. 2014
  4. Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases Endocrine. 2015
  5. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone J Clin Endocrinol Metab. 2001
  6. GH-independent cardiotropic activities of hexarelin in patients with severe left ventricular dysfunction due to dilated and ischemic cardiomyopathy Eur J Heart Fail. 2002
  7. Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery Eur J Pharmacol. 2002
  8. Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging Eur J Endocrinol. 1996
  9. The Safety and Efficacy of Growth Hormone Secretagogues Sex Med Rev. 2018
  10. PubChem compound record for hexarelin (CID 6918297; CAS 140703-51-1) PubChem. 2026

Last reviewed October 22, 2026 by the Amiravo editorial team. Editorial policy · Report an error