Immune & Inflammation · Dosing reference

KPV dosage

What the human evidence does and does not show, how long studies ran, and the arithmetic for working with vials.

Not approved — research use onlyCPreclinical researchNone established

Full research page Cycle-length evidence Compare Prefer Amiravo on Google

Regulatory status: Not approved — research use only
Human amounts: None established in humans
Route studied: —
Frequency: Not established
Half-life: Not established
Evidence grade: Grade C · Preclinical research
Vial sizes on the market: 5 mg · 10 mg
Other forms seen: —

What KPV is

KPV is a short tripeptide fragment derived from alpha-melanocyte-stimulating hormone, studied in cell and mouse models of intestinal inflammation signaling. All evidence cited here is preclinical.

KPV is the tripeptide alpha-MSH(11-13), derived from the melanocortin hormone alpha-MSH ^1. Reported mechanisms Inflammatory signaling: In human intestinal epithelial cell lines (Caco2-BBE, HT29-Cl.19A) and Jurkat T cells, nanomolar KPV was reported to inhibit NF-kappaB and MAP kinase activation and reduce pro-inflammatory cytokine secretion ^3. Cellular uptake: The same study reported that KPV acts through PepT1,… How it works →

Key evidence

Kannengiesser et al., Inflamm Bowel Dis · 2008 · Animals (mice)
KPV was associated with earlier weight recovery, reduced histological inflammation and reduced myeloperoxidase activity, and with survival in MC1R-nonfunctional mice. ¹
Dalmasso et al., Gastroenterology · 2008 · Cells (human intestinal epithelial and T-cell lines) and animals (mice)
Nanomolar KPV was reported to inhibit NF-kappaB and MAP kinase pathways via PepT1, and oral KPV reduced colitis incidence in mice. ³
Xiao et al., Mol Ther · 2017 · Cells and animals (mouse colitis model)
Hyaluronic acid-functionalized nanoparticles carrying KPV were reported to promote mucosal healing and reduce TNF-alpha in mouse colitis. ²

All studies on the research page

What the human evidence shows

No approved or established human dose

We searched PubMed and ClinicalTrials.gov and found no human studies that administered KPV. The research described on its page is from cells or animals, and animal amounts do not translate to people.

How long did human studies run?

No human study durations are recorded for KPV.

Cycle-length evidence for KPV

KPV draw calculator

Pick the vial strength and the water added, enter an amount, and see the concentration, the units to draw and how many draws the vial holds. Arithmetic only.

1 · Vial strength

sizes on the market

2 · Water added

3 · Amount per draw

4 · Syringe

Your mix

10 mg + 2 mL water = 5 mg/mL

10 units holds 0.5 mg (500 mcg)

Draw toEnter an amount in step 3

U-100 syringe · 100 units = 1 mL

Computed from your inputs. Not a dose or a recommendation.

Compare water volumes for this vialShow

More water = lower concentration = a larger, easier-to-measure draw. Tap a row to use it.

Water	mg/mL	Draw
0.5 mL	20	—
1 mL	10	—
1.5 mL	6.667	—
2 mL	5	—
2.5 mL	4	—
3 mL	3.333	—
5 mL	2	—

Supplies and handling

Lyophilized vial
Sealed vial with the freeze-dried cake. Check the label, lot and the certificate of analysis before opening.
Sterile diluent
The diluent named on the product documentation. Bacteriostatic water contains benzyl alcohol; sterile water does not.
Graduated syringes
Sized to the volume being measured. U-100 insulin syringes are graduated in units where 100 units = 1 mL.
Alcohol prep pads
For wiping vial stoppers before each puncture.
Nitrile gloves
Clean gloves for aseptic handling.
Sharps container
Puncture-resistant container for used needles.

Step-by-step reconstitution guide Storage and transport accessories

Storage

Handle according to the supplier's documentation for the specific lot; short peptides are generally kept dry and protected from light and moisture in research settings.

Lyophilized (unmixed) vials: typically stored cold and dry, away from light, as the documentation directs. Many are stable longer frozen.
Reconstituted vials: typically refrigerated (about 2–8 °C), protected from light and not frozen.
Bacteriostatic water contains benzyl alcohol, which inhibits bacterial growth in multi-use vials; sterile water has no preservative.

Handling mistakes and troubleshooting

Added the wrong volume of diluent: The concentration changes, not the amount of compound in the vial. Recalculate with the volume actually added and relabel the vial.
Shook the vial and it foamed: Let it settle in the refrigerator. Foam is a sign of agitation; some peptides aggregate when shaken. Note it on the label.
The solution is cloudy or has particles: Do not use it. Cloudiness can indicate incomplete dissolution, contamination or degradation. Record the lot and contact the supplier with the certificate of analysis.
The powder cake looks melted or shrunken before reconstitution: This can indicate the vial was exposed to heat or moisture. Record the lot and condition on arrival.
Liquid sprayed back when the needle was removed: Pressure built up in the vial. Withdraw a small volume of air while adding diluent to keep pressure neutral.

Regulatory status

Status: Not approved by the FDA for any use; studied only in cell and animal models in the sources reviewed ^1,2,3.
United States (FDA): No FDA-approved label for KPV was identified; it is not approved for any indication ^1.
Sport (WADA): KPV is not named in the 2026 WADA Prohibited List text reviewed; Section S0 covers substances with no governmental approval for human therapeutic use, so status should be confirmed with the relevant anti-doping organization ^4.

Status varies by country and changes over time. How we describe regulatory status.

KPV compared with related compounds

Compound	Status	Evidence	Human amounts	Half-life
KPV	Not approved — research use only	C	None established	—
Vesugen	Not approved — research use only	C	None established	—
Thymulin	Not approved — research use only	C	None established	Not located in the sources reviewed for
Larazotide	Investigational	B	Trial doses	—
LL-37	Not approved — research use only	B	None established	—
Thymosin Alpha-1	Approved outside the US	B	None established	—

Combinations that include KPV

KLOW (BPC-157 + TB-500 + GHK-Cu + KPV)

Frequently asked questions

What doses of KPV have been studied in humans?

None that establish an amount. KPV is not approved anywhere and we found no human studies that administered it. Amiravo does not publish community or vendor figures.

Is there an established KPV cycle length?

No. We found no human studies that report treatment duration for KPV.

How much bacteriostatic water should be added to a KPV vial?

There is no compound-specific volume. The diluent volume only sets the concentration: concentration = mass in the vial ÷ volume added (for example, 10 mg in 2 mL gives 5 mg/mL). The calculator on this page shows the arithmetic for any combination.

How many units is a given amount on an insulin syringe?

On a U-100 syringe, 100 units = 1 mL. Units for an amount = amount ÷ (concentration per unit). The calculator converts any amount you enter at the concentration you choose; a unit is a volume mark, not an amount of compound.

Is KPV FDA-approved?

Not approved — research use only. Not approved by the FDA for any use; studied only in cell and animal models in the sources reviewed ^1,2,3.

References

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease Inflamm Bowel Dis. 2008
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis Mol Ther. 2017
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation Gastroenterology. 2008
WADA 2026 Prohibited List World Anti-Doping Agency. 2026
ClinicalTrials.gov intervention-field search for KPV (no studies returned) ClinicalTrials.gov. 2026

Last reviewed October 23, 2026 by the Amiravo editorial team. Editorial policy · Report an error