Bioregulators · Dosing reference

Vesugen dosage

What the human evidence does and does not show, how long studies ran, and the arithmetic for working with vials.

Not approved — research use onlyCPreclinical researchNone established

Full research page Cycle-length evidence Compare Prefer Amiravo on Google

Regulatory status: Not approved — research use only
Human amounts: None established in humans
Route studied: —
Frequency: Not established
Half-life: Not established
Evidence grade: Grade C · Preclinical research
Vial sizes on the market: 20 mg
Other forms seen: —

What Vesugen is

A short synthetic bioregulator peptide, studied in research on vascular tissue and endothelial cell biology.

Vesugen's investigators propose an epigenetic mechanism in which the tripeptide enters cells, reaches DNA, and influences transcription of genes governing endothelial proliferation and function ^1,4. Docking predictions and proliferation markers In tissue-specific cultures from young and old animals and in dissociated vascular endothelial cell cultures, vesugen was reported to stimulate expression of the… How it works →

Key evidence

Khavinson et al., Advances in Gerontology (in Russian) · 2014 · Vascular endothelial and tissue-specific cell cultures from young and old animals (in vitro), plus in silico docking
Vesugen was reported to stimulate Ki-67 expression, and docking predicted contact with a defined core promoter sequence of MKI67 near the transcription start site. ¹
Kitachev et al., Advances in Gerontology (in Russian) · 2014 · Humans (41 patients with vasculogenic erectile dysfunction attributed to atherosclerosis)
Blood flow in the main penile arteries was reported as improved after treatment on both clinical and objective measures. ²
Kozlov et al., Advances in Gerontology (in Russian) · 2016 · Normal, atherosclerotic and restenotic endothelial cells (in vitro)
The tripeptide was reported to normalise endothelin-1 expression, restore connexin expression and increase sirtuin 1 expression. ⁴

All studies on the research page

What the human evidence shows

No approved or established human dose

We searched PubMed and ClinicalTrials.gov and found no human studies that administered Vesugen. The research described on its page is from cells or animals, and animal amounts do not translate to people.

How long did human studies run?

No human study durations are recorded for Vesugen.

Cycle-length evidence for Vesugen

Who was excluded from the studies

The indexed studies enrolled adults, mainly older adults; no study in children, pregnancy or lactation was identified ^11,13.

Vesugen draw calculator

Pick the vial strength and the water added, enter an amount, and see the concentration, the units to draw and how many draws the vial holds. Arithmetic only.

1 · Vial strength

sizes on the market

2 · Water added

3 · Amount per draw

4 · Syringe

Your mix

20 mg + 2 mL water = 10 mg/mL

10 units holds 1 mg

Draw toEnter an amount in step 3

U-100 syringe · 100 units = 1 mL

Computed from your inputs. Not a dose or a recommendation.

Compare water volumes for this vialShow

More water = lower concentration = a larger, easier-to-measure draw. Tap a row to use it.

Water	mg/mL	Draw
0.5 mL	40	—
1 mL	20	—
1.5 mL	13.33	—
2 mL	10	—
2.5 mL	8	—
3 mL	6.667	—
5 mL	4	—

Supplies and handling

Lyophilized vial
Sealed vial with the freeze-dried cake. Check the label, lot and the certificate of analysis before opening.
Sterile diluent
The diluent named on the product documentation. Bacteriostatic water contains benzyl alcohol; sterile water does not.
Graduated syringes
Sized to the volume being measured. U-100 insulin syringes are graduated in units where 100 units = 1 mL.
Alcohol prep pads
For wiping vial stoppers before each puncture.
Nitrile gloves
Clean gloves for aseptic handling.
Sharps container
Puncture-resistant container for used needles.

Step-by-step reconstitution guide Storage and transport accessories

Storage

General research-context handling only: lyophilised short peptides are normally kept cold, dry and protected from light, and reconstituted material is far less stable than the dry powder. Amiravo gives no preparation, reconstitution or handling instructions; defer to the supplier's own documentation and to local institutional requirements for research materials.

Lyophilized (unmixed) vials: typically stored cold and dry, away from light, as the documentation directs. Many are stable longer frozen.
Reconstituted vials: typically refrigerated (about 2–8 °C), protected from light and not frozen.
Bacteriostatic water contains benzyl alcohol, which inhibits bacterial growth in multi-use vials; sterile water has no preservative.

Handling mistakes and troubleshooting

Added the wrong volume of diluent: The concentration changes, not the amount of compound in the vial. Recalculate with the volume actually added and relabel the vial.
Shook the vial and it foamed: Let it settle in the refrigerator. Foam is a sign of agitation; some peptides aggregate when shaken. Note it on the label.
The solution is cloudy or has particles: Do not use it. Cloudiness can indicate incomplete dissolution, contamination or degradation. Record the lot and contact the supplier with the certificate of analysis.
The powder cake looks melted or shrunken before reconstitution: This can indicate the vial was exposed to heat or moisture. Record the lot and condition on arrival.
Liquid sprayed back when the needle was removed: Pressure built up in the vial. Withdraw a small volume of air while adding diluent to keep pressure neutral.

Regulatory status

Status: Not approved by the FDA for any use; no approved application and no structured product label were identified ^6,7.
United States (FDA): No approved application for this substance was identified in Drugs@FDA, and no structured product label for it was identified in DailyMed ^6,7. It does not appear in any of the three categories of FDA's 503A bulk drug substances list as updated May 14, 2026 (Category 1, substances under evaluation; Category 2, substances raising significant safety risks; Category 3, substances nominated without adequate support) ^8.
Sport (WADA): The substance is not named anywhere in the WADA 2026 Prohibited List ^9. Absence of a name is not a clearance: several classes on the List are written as open categories using wording such as "including, but not limited to", and section S0 (Non-Approved Substances) is written to cover pharmacological substances that are not addressed elsewhere on the List and that have no current approval from a governmental health authority for human therapeutic use, a description that fits an unapproved research peptide ^9. Whether any particular substance falls inside S0 or inside an open class is a determination for anti-doping authorities, not something that can be read off the absence of a name.

Status varies by country and changes over time. How we describe regulatory status.

Vesugen compared with related compounds

Compound	Status	Evidence	Human amounts	Half-life
Vesugen	Not approved — research use only	C	None established	—
Pinealon	Not approved — research use only	C	None established	—
Testagen	Not approved — research use only	D	None established	—
Prostamax	Not approved — research use only	D	None established	—
Bronchogen	Not approved — research use only	C	None established	—
Cortagen	Not approved — research use only	C	None established	—

Frequently asked questions

What doses of Vesugen have been studied in humans?

None that establish an amount. Vesugen is not approved anywhere and we found no human studies that administered it. Amiravo does not publish community or vendor figures.

Is there an established Vesugen cycle length?

No. We found no human studies that report treatment duration for Vesugen.

How much bacteriostatic water should be added to a Vesugen vial?

There is no compound-specific volume. The diluent volume only sets the concentration: concentration = mass in the vial ÷ volume added (for example, 10 mg in 2 mL gives 5 mg/mL). The calculator on this page shows the arithmetic for any combination.

How many units is a given amount on an insulin syringe?

On a U-100 syringe, 100 units = 1 mL. Units for an amount = amount ÷ (concentration per unit). The calculator converts any amount you enter at the concentration you choose; a unit is a volume mark, not an amount of compound.

Is Vesugen FDA-approved?

Not approved — research use only. Not approved by the FDA for any use; no approved application and no structured product label were identified ^6,7.

References

[Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging] Adv Gerontol. 2014
[The efficacy of peptide bioregulators of vessels in lower limbs chronic arterial insufficiency treatment in old and elderly people] Adv Gerontol. 2014
Short peptides stimulate serotonin expression in cells of brain cortex Bull Exp Biol Med. 2014
[Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis] Adv Gerontol. 2016
Peptides tissue-specifically stimulate cell differentiation during their aging Bull Exp Biol Med. 2012
Drugs@FDA: FDA-Approved Drugs (search of approved applications) FDA Drugs@FDA / openFDA drug/drugsfda. 2026
DailyMed label search (structured product labels) NLM DailyMed. 2026
Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the FD&C Act, updated May 14, 2026 FDA. 2026
World Anti-Doping Code International Standard: Prohibited List 2026 WADA. 2026
Effect of short peptides on expression of signaling molecules in organotypic pineal cell culture Bull Exp Biol Med. 2011
[The role of vasoactive peptid in lower limbs chronic arterial insufficiency treatment] Adv Gerontol. 2013
[TREATMENT OF CHEMICAL STOMATITIS IN PEOPLE OF ADVANCED AND SENILE AGE] Adv Gerontol. 2013
[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION] Adv Gerontol. 2015
[Comparative analysis of different methods of geroprotective] Adv Gerontol. 2016

Last reviewed October 23, 2026 by the Amiravo editorial team. Editorial policy · Report an error