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For research use only. Not for human or veterinary use. Not a drug, food, or dietary supplement.
AMIRAVOResearch Library
Hormonal · Dosing reference

Kisspeptin-10 dosage

What the human evidence does and does not show, how long studies ran, and the arithmetic for working with vials.

Not approved — research use onlyBLimited human dataNone established
Full research pageCycle-length evidenceComparePrefer Amiravo on Google
Regulatory status
Not approved — research use only
Human amounts
None established in humans
Route studied
—
Frequency
Not established
Half-life
Not established
Evidence grade
Grade B · Limited human data
Vial sizes on the market
10 mg
Other forms seen
—

What Kisspeptin-10 is

A short peptide fragment of kisspeptin, the KISS1 gene product, studied in research on reproductive neuroendocrine signaling.

Kisspeptins are the products of the KISS1 gene and signal through the G protein-coupled receptor KISS1R, also known as GPR54; the system has been described as multifunctional, with roles reported in reproduction, cancer biology and the cardiovascular system 4. Reproductive axis Kisspeptin acts on hypothalamic neurons to drive gonadotropin-releasing hormone secretion, which in turn raises luteinizing hormone and… How it works →

Key evidence

  • Hori et al., Biochem Biophys Res Commun · 2001 · Cells (CHO transfected with the human kisspeptin receptor)
    Metastin and its truncated forms, including the sequence corresponding to kisspeptin-10, suppressed cell motility and growth in receptor-transfected cells. 5
  • George et al., J Clin Endocrinol Metab · 2011 · Humans (healthy men)
    Kisspeptin-10 produced a rapid dose-dependent rise in LH; infusion raised mean LH and testosterone and increased LH pulse frequency and pulse mass. A higher bolus produced a smaller response than a lower one. 6
  • Yeung et al., Eur J Endocrinol · 2026 · Humans (15 healthy men, 12 controls)
    Acute infusion raised LH, FSH and testosterone dose-dependently; five days of continuous infusion left gonadotropins similar to vehicle; daily intermittent infusion sustained gonadotropin elevation over 12 days. 7
All studies on the research page

What the human evidence shows

No approved or established human dose

We searched PubMed and ClinicalTrials.gov and found no human studies that administered Kisspeptin-10. The research described on its page is from cells or animals, and animal amounts do not translate to people.

How long did human studies run?

No human study durations are recorded for Kisspeptin-10.

Cycle-length evidence for Kisspeptin-10

Side effects reported in studies

  • No adverse effects reported
    0 reported · Randomized crossover trial in 32 premenopausal women with hypoactive sexual desire disorder, using kisspeptin-54 10
  • No significant change in cortisol, systolic or diastolic blood pressure, or heart rate
    No between-arm difference · 95 healthy participants, crossover study using kisspeptin-54 8
Full adverse-event data

Kisspeptin-10 draw calculator

Pick the vial strength and the water added, enter an amount, and see the concentration, the units to draw and how many draws the vial holds. Arithmetic only.

1 · Vial strength
sizes on the market
2 · Water added
3 · Amount per draw
4 · Syringe
Your mix
10 mg + 2 mL water = 5 mg/mL
10 units holds 0.5 mg (500 mcg)
Draw toEnter an amount in step 3
0102030405060708090100
U-100 syringe · 100 units = 1 mL

Computed from your inputs. Not a dose or a recommendation.

Compare water volumes for this vialShow

More water = lower concentration = a larger, easier-to-measure draw. Tap a row to use it.

Watermg/mLDraw
0.5 mL20—
1 mL10—
1.5 mL6.667—
2 mL5—
2.5 mL4—
3 mL3.333—
5 mL2—

Supplies and handling

  • Lyophilized vial
    Sealed vial with the freeze-dried cake. Check the label, lot and the certificate of analysis before opening.
  • Sterile diluent
    The diluent named on the product documentation. Bacteriostatic water contains benzyl alcohol; sterile water does not.
  • Graduated syringes
    Sized to the volume being measured. U-100 insulin syringes are graduated in units where 100 units = 1 mL.
  • Alcohol prep pads
    For wiping vial stoppers before each puncture.
  • Nitrile gloves
    Clean gloves for aseptic handling.
  • Sharps container
    Puncture-resistant container for used needles.
Step-by-step reconstitution guideStorage and transport accessories

Storage

General research-context handling only. Lyophilised short peptides are usually kept cold, dry and protected from light and from repeated temperature cycling, with reconstituted material treated as far less stable than the dry powder. Follow the storage conditions, retest date and solubility guidance in the supplier's documentation for the specific lot; this entry gives no preparation, concentration or handling instructions.

  • Lyophilized (unmixed) vials: typically stored cold and dry, away from light, as the documentation directs. Many are stable longer frozen.
  • Reconstituted vials: typically refrigerated (about 2–8 °C), protected from light and not frozen.
  • Bacteriostatic water contains benzyl alcohol, which inhibits bacterial growth in multi-use vials; sterile water has no preservative.

Handling mistakes and troubleshooting

Added the wrong volume of diluent
The concentration changes, not the amount of compound in the vial. Recalculate with the volume actually added and relabel the vial.
Shook the vial and it foamed
Let it settle in the refrigerator. Foam is a sign of agitation; some peptides aggregate when shaken. Note it on the label.
The solution is cloudy or has particles
Do not use it. Cloudiness can indicate incomplete dissolution, contamination or degradation. Record the lot and contact the supplier with the certificate of analysis.
The powder cake looks melted or shrunken before reconstitution
This can indicate the vial was exposed to heat or moisture. Record the lot and condition on arrival.
Liquid sprayed back when the needle was removed
Pressure built up in the vial. Withdraw a small volume of air while adding diluent to keep pressure neutral.

Regulatory status

Status
Kisspeptin-10 has no approved drug application in the United States; a Drugs@FDA / openFDA search for kisspeptin returns no records 1. FDA places "Kisspeptin-10" in Category 2 of its 503A nominated bulk drug substances document, the category described as substances that raise significant safety risks 2. Kisspeptin is named in the WADA 2026 Prohibited List, section S2.2.1 3.
United States (FDA)
Not approved. A Drugs@FDA / openFDA query for "kisspeptin" returns no matching applications 1. In FDA's document "Bulk Drug Substances Nominated for Use in Compounding Under Section 503A" (updated May 14, 2026), "Kisspeptin-10" is listed under "503A Category 2: Bulk Drug Substances that Raise Significant Safety Risks" 2.
Sport (WADA)
Prohibited at all times. Section S2.2.1, "Testosterone-stimulating peptides in males including, but not limited to:", names "kisspeptin and its agonist analogues" 3. Class S2 substances are prohibited in- and out-of-competition and are non-Specified.

Status varies by country and changes over time. How we describe regulatory status.

Kisspeptin-10 compared with related compounds

CompoundStatusEvidenceHuman amountsHalf-life
Kisspeptin-10Not approved — research use onlyBNone established—
Kisspeptin-54Not approved — research use onlyBNone establishedAbout 28 minutes (intravenous, healthy m
GonadorelinApproved, no longer marketedBLabel not retrievableA review describes native GnRH as having
NAD+Not approved — research use onlyBNone established—
VesugenNot approved — research use onlyCNone established—
LivagenNot approved — research use onlyCNone established—

Frequently asked questions

What doses of Kisspeptin-10 have been studied in humans?
None that establish an amount. Kisspeptin-10 is not approved anywhere and we found no human studies that administered it. Amiravo does not publish community or vendor figures.
Is there an established Kisspeptin-10 cycle length?
No. We found no human studies that report treatment duration for Kisspeptin-10.
How much bacteriostatic water should be added to a Kisspeptin-10 vial?
There is no compound-specific volume. The diluent volume only sets the concentration: concentration = mass in the vial ÷ volume added (for example, 10 mg in 2 mL gives 5 mg/mL). The calculator on this page shows the arithmetic for any combination.
How many units is a given amount on an insulin syringe?
On a U-100 syringe, 100 units = 1 mL. Units for an amount = amount ÷ (concentration per unit). The calculator converts any amount you enter at the concentration you choose; a unit is a volume mark, not an amount of compound.
Is Kisspeptin-10 FDA-approved?
Not approved — research use only. Kisspeptin-10 has no approved drug application in the United States; a Drugs@FDA / openFDA search for kisspeptin returns no records 1. FDA places "Kisspeptin-10" in Category 2 of its 503A nominated bulk drug substances document, the category described as substances that raise significant safety risks 2. Kisspeptin is named in the WADA 2026 Prohibited List, section S2.2.1 3.

References

  1. Drugs@FDA application data queried through openFDA for kisspeptin (no matching application record returned on 22 October 2026) openFDA / Drugs@FDA. 2026
  2. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the FD&C Act (categories 1, 2 and 3; updated May 14, 2026) FDA. 2026
  3. International Standard: Prohibited List 2026 World Anti-Doping Agency. 2026
  4. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system Br J Pharmacol. 2007
  5. Metastin suppresses the motility and growth of CHO cells transfected with its receptor Biochem Biophys Res Commun. 2001
  6. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men J Clin Endocrinol Metab. 2011
  7. Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men Eur J Endocrinol. 2026
  8. Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans J Clin Endocrinol Metab. 2025
  9. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial JAMA Netw Open. 2023
  10. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial JAMA Netw Open. 2022
  11. PubChem compound record for kisspeptin-10 (CID 25240297; CAS 374675-21-5) PubChem. 2026

Last reviewed October 22, 2026 by the Amiravo editorial team. Editorial policy · Report an error