Cognitive · Dosing reference

Selank dosage

What the human evidence does and does not show, how long studies ran, and the arithmetic for working with vials.

Approved outside the USBLimited human dataNone established

Full research page Cycle-length evidence Compare Prefer Amiravo on Google

Regulatory status: Approved outside the US
Human amounts: None established in humans
Route studied: —
Frequency: Not established
Half-life: Not established
Evidence grade: Grade B · Limited human data
Vial sizes on the market: 5 mg · 10 mg · 30 mg
Other forms seen: Liquid spray 10 mL (5 mg, 0.5 mg/mL) · Nasal spray 0.15% (1.5 mg/mL)

What Selank is

Selank is a synthetic heptapeptide analogue of tuftsin, studied in rodents and cell membranes for effects on GABAergic and opioid-related signaling. Small Russian-language clinical studies exist, and it is reported to be registered as a drug in Russia but not in the United States.

The mechanism of Selank is not settled; several laboratory observations have been reported ^1,2,5. GABAergic signaling (cells, membranes, rats) In radioligand experiments on brain-cell membranes, Selank affected [3H]GABA binding as a positive allosteric modulator ^1. The same work reported that combined Selank and benzodiazepine action on GABA binding was not additive, and that Selank could block the modulatory… How it works →

Key evidence

Zozulya et al., Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · 2008 · Humans (62 patients with generalized anxiety disorder or neurasthenia)
Anxiolytic effects were reported as similar between the two agents, with additional anti-asthenic and psychostimulant effects for Selank; leu-enkephalin half-life measures changed during Selank treatment. ³
Uchakina et al., Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · 2008 · Humans (patients with anxiety-asthenic disorders) and cultured blood cells
Changes in Th1/Th2 cytokine balance were reported in treated patients; in vitro, IL-6 expression was suppressed in cells from patients with depression but not healthy controls. ⁴
Volkova et al., Frontiers in Pharmacology · 2016 · Rats (frontal cortex)
45 genes changed at 1 hour and 22 at 3 hours; expression changes correlated positively with those of GABA. ²

All studies on the research page

What the human evidence shows

No approved or established human dose

We searched PubMed and ClinicalTrials.gov and found no human studies that administered Selank. The research described on its page is from cells or animals, and animal amounts do not translate to people.

How long did human studies run?

No human study durations are recorded for Selank.

Cycle-length evidence for Selank

Selank draw calculator

Pick the vial strength and the water added, enter an amount, and see the concentration, the units to draw and how many draws the vial holds. Arithmetic only.

1 · Vial strength

sizes on the market

2 · Water added

3 · Amount per draw

4 · Syringe

Your mix

10 mg + 2 mL water = 5 mg/mL

10 units holds 0.5 mg (500 mcg)

Draw toEnter an amount in step 3

U-100 syringe · 100 units = 1 mL

Computed from your inputs. Not a dose or a recommendation.

Compare water volumes for this vialShow

More water = lower concentration = a larger, easier-to-measure draw. Tap a row to use it.

Water	mg/mL	Draw
0.5 mL	20	—
1 mL	10	—
1.5 mL	6.667	—
2 mL	5	—
2.5 mL	4	—
3 mL	3.333	—
5 mL	2	—

Supplies and handling

Lyophilized vial
Sealed vial with the freeze-dried cake. Check the label, lot and the certificate of analysis before opening.
Sterile diluent
The diluent named on the product documentation. Bacteriostatic water contains benzyl alcohol; sterile water does not.
Graduated syringes
Sized to the volume being measured. U-100 insulin syringes are graduated in units where 100 units = 1 mL.
Alcohol prep pads
For wiping vial stoppers before each puncture.
Nitrile gloves
Clean gloves for aseptic handling.
Sharps container
Puncture-resistant container for used needles.

Step-by-step reconstitution guide Storage and transport accessories

Storage

Follow the supplier's documentation for temperature, light and moisture protection of the lyophilized or dissolved material, and avoid repeated freeze-thaw cycles. Stability of solutions is supplier- and lot-specific.

Lyophilized (unmixed) vials: typically stored cold and dry, away from light, as the documentation directs. Many are stable longer frozen.
Reconstituted vials: typically refrigerated (about 2–8 °C), protected from light and not frozen.
Bacteriostatic water contains benzyl alcohol, which inhibits bacterial growth in multi-use vials; sterile water has no preservative.

Handling mistakes and troubleshooting

Added the wrong volume of diluent: The concentration changes, not the amount of compound in the vial. Recalculate with the volume actually added and relabel the vial.
Shook the vial and it foamed: Let it settle in the refrigerator. Foam is a sign of agitation; some peptides aggregate when shaken. Note it on the label.
The solution is cloudy or has particles: Do not use it. Cloudiness can indicate incomplete dissolution, contamination or degradation. Record the lot and contact the supplier with the certificate of analysis.
The powder cake looks melted or shrunken before reconstitution: This can indicate the vial was exposed to heat or moisture. Record the lot and condition on arrival.
Liquid sprayed back when the needle was removed: Pressure built up in the vial. Withdraw a small volume of air while adding diluent to keep pressure neutral.

Regulatory status

Status: Not approved by the FDA; a DailyMed name search for this entry returned no label ^7. A 2022 peer-reviewed review lists Selank among 14 original peptide drugs registered in the Russian Federation, classed as an anxiolytic ^6. The Russian State Register entry itself could not be accessed for this entry, so the registered indication and date were not verified against it.
United States (FDA): Selank is not FDA-approved; a DailyMed name search for this entry returned no label ^7. A 2022 peer-reviewed review lists Selank (classed as an anxiolytic) among 14 peptide drugs registered in the Russian Federation ^6. Status in other jurisdictions was not verified.
Sport (WADA): The WADA 2026 Prohibited List text reviewed (sections S0 and S2.2) does not name Selank among its listed examples ^8. Athlete status therefore is not determined here, and the List should be consulted directly ^8.

Status varies by country and changes over time. How we describe regulatory status.

Selank compared with related compounds

Compound	Status	Evidence	Human amounts	Half-life
Selank	Approved outside the US	B	None established	—
Vesugen	Not approved — research use only	C	None established	—
Cerebrolysin	Approved outside the US	A	Ex-US label	Not directly measurable (peptide mixture
Semax	Approved outside the US	B	None established	—
Dihexa	Not approved — research use only	C	None established	—
DSIP	Not approved — research use only	B	None established	—

Combinations that include Selank

Selank + Semax

Frequently asked questions

What doses of Selank have been studied in humans?

None that establish an amount. Selank is not approved anywhere and we found no human studies that administered it. Amiravo does not publish community or vendor figures.

Is there an established Selank cycle length?

No. We found no human studies that report treatment duration for Selank.

How much bacteriostatic water should be added to a Selank vial?

There is no compound-specific volume. The diluent volume only sets the concentration: concentration = mass in the vial ÷ volume added (for example, 10 mg in 2 mL gives 5 mg/mL). The calculator on this page shows the arithmetic for any combination.

How many units is a given amount on an insulin syringe?

On a U-100 syringe, 100 units = 1 mL. Units for an amount = amount ÷ (concentration per unit). The calculator converts any amount you enter at the concentration you choose; a unit is a volume mark, not an amount of compound.

Is Selank FDA-approved?

Approved outside the US. Not approved by the FDA; a DailyMed name search for this entry returned no label ^7. A 2022 peer-reviewed review lists Selank among 14 original peptide drugs registered in the Russian Federation, classed as an anxiolytic ^6. The Russian State Register entry itself could not be accessed for this entry, so the registered indication and date were not verified against it.

References

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity Protein Pept Lett. 2018
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission Front Pharmacol. 2016
Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia (in Russian) Zh Nevrol Psikhiatr Im S S Korsakova. 2008
Immunomodulatory effects of selank in patients with anxiety-asthenic disorders (in Russian) Zh Nevrol Psikhiatr Im S S Korsakova. 2008
Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system Bull Exp Biol Med. 2006
Development of Peptide Biopharmaceuticals in Russia Pharmaceutics. 2022
DailyMed drug-label search for selank (conducted for this entry) FDA DailyMed. 2026
WADA International Standard: Prohibited List 2026 (S0 and S2.2) WADA Prohibited List. 2026
PubChem CID 11765600 (Selank) PubChem. 2026
Comparison of pharmacological effects of heptapeptide selank after intranasal and intraperitoneal administration to BALB/c and C57BL/6 mice (in Russian) Eksp Klin Farmakol. 2016
ClinicalTrials.gov intervention search for selank (conducted for this entry) ClinicalTrials.gov. 2026

Last reviewed October 22, 2026 by the Amiravo editorial team. Editorial policy · Report an error