Cognitive · Dosing reference

DSIP dosage

What the human evidence does and does not show, how long studies ran, and the arithmetic for working with vials.

Not approved — research use onlyBLimited human dataNone established

Full research page Cycle-length evidence Compare Prefer Amiravo on Google

Regulatory status: Not approved — research use only
Human amounts: None established in humans
Route studied: —
Frequency: Not established
Half-life: Not established
Evidence grade: Grade B · Limited human data
Vial sizes on the market: 5 mg · 10 mg
Other forms seen: Liquid spray blend 10 mL (DSIP 10 mg with pinealon, melatonin, GABA)

What DSIP is

DSIP is a naturally occurring neuropeptide first isolated from rabbit brain, investigated in sleep, stress and neuroendocrine research.

No receptor, gene or signalling pathway for DSIP has been established. The peptide was isolated on the basis of a biological activity rather than a molecular target, and a 2006 review states that the link between DSIP and sleep has never been further characterised, in part because the DSIP gene, protein and any related receptor were never isolated ^5. The identity problem That review goes further and hypothesises… How it works →

Key evidence

Schneider-Helmert, Eur Neurol · 1987 · Humans (14 middle-aged chronic insomniacs)
Night sleep improved with first and repeated administration and the effect persisted into the first post-treatment placebo night; daytime alertness and performance increased. A positive result in a very small sample. ⁷
Bes et al., Neuropsychobiology · 1992 · Humans (16 chronic insomniacs)
Sleep efficiency and sleep latency favoured DSIP, but the authors judged the effects weak and partly due to an incidental change in the placebo group; subjective sleep quality did not change, and they concluded short-term treatment was unlikely to be of major therapeutic benefit. ⁸
Kovalzon and Strekalova, J Neurochem · 2006 · Review, drawing on rabbit and rat work
Concluded that the DSIP-as-sleep-factor hypothesis is extremely poorly documented and still weak, noting that no DSIP gene, protein or receptor has been isolated and that artificial analogues rather than DSIP itself promoted slow-wave sleep in their earlier animal studies. ⁵

All studies on the research page

What the human evidence shows

No approved or established human dose

We searched PubMed and ClinicalTrials.gov and found no human studies that administered DSIP. The research described on its page is from cells or animals, and animal amounts do not translate to people.

How long did human studies run?

No human study durations are recorded for DSIP.

Cycle-length evidence for DSIP

DSIP draw calculator

Pick the vial strength and the water added, enter an amount, and see the concentration, the units to draw and how many draws the vial holds. Arithmetic only.

1 · Vial strength

sizes on the market

2 · Water added

3 · Amount per draw

4 · Syringe

Your mix

10 mg + 2 mL water = 5 mg/mL

10 units holds 0.5 mg (500 mcg)

Draw toEnter an amount in step 3

U-100 syringe · 100 units = 1 mL

Computed from your inputs. Not a dose or a recommendation.

Compare water volumes for this vialShow

More water = lower concentration = a larger, easier-to-measure draw. Tap a row to use it.

Water	mg/mL	Draw
0.5 mL	20	—
1 mL	10	—
1.5 mL	6.667	—
2 mL	5	—
2.5 mL	4	—
3 mL	3.333	—
5 mL	2	—

Supplies and handling

Lyophilized vial
Sealed vial with the freeze-dried cake. Check the label, lot and the certificate of analysis before opening.
Sterile diluent
The diluent named on the product documentation. Bacteriostatic water contains benzyl alcohol; sterile water does not.
Graduated syringes
Sized to the volume being measured. U-100 insulin syringes are graduated in units where 100 units = 1 mL.
Alcohol prep pads
For wiping vial stoppers before each puncture.
Nitrile gloves
Clean gloves for aseptic handling.
Sharps container
Puncture-resistant container for used needles.

Step-by-step reconstitution guide Storage and transport accessories

Storage

General research-context handling only. Lyophilised peptide is normally kept cold, dry and shielded from light, and tryptophan-containing sequences are particularly light- and oxidation-sensitive once dissolved. Defer to the storage temperature, retest date and solvent guidance in the supplier's documentation for the specific lot. No preparation or handling instructions are given here.

Lyophilized (unmixed) vials: typically stored cold and dry, away from light, as the documentation directs. Many are stable longer frozen.
Reconstituted vials: typically refrigerated (about 2–8 °C), protected from light and not frozen.
Bacteriostatic water contains benzyl alcohol, which inhibits bacterial growth in multi-use vials; sterile water has no preservative.

Handling mistakes and troubleshooting

Added the wrong volume of diluent: The concentration changes, not the amount of compound in the vial. Recalculate with the volume actually added and relabel the vial.
Shook the vial and it foamed: Let it settle in the refrigerator. Foam is a sign of agitation; some peptides aggregate when shaken. Note it on the label.
The solution is cloudy or has particles: Do not use it. Cloudiness can indicate incomplete dissolution, contamination or degradation. Record the lot and contact the supplier with the certificate of analysis.
The powder cake looks melted or shrunken before reconstitution: This can indicate the vial was exposed to heat or moisture. Record the lot and condition on arrival.
Liquid sprayed back when the needle was removed: Pressure built up in the vial. Withdraw a small volume of air while adding diluent to keep pressure neutral.

Regulatory status

Status: DSIP (delta sleep-inducing peptide), referred to by FDA as emideltide, has no approved drug application in the United States; Drugs@FDA / openFDA searches return no records ^1. Emideltide-related bulk drug substances were on the agenda of FDA's Pharmacy Compounding Advisory Committee meeting of July 23-24, 2026, where FDA proposed that emideltide (free base) and emideltide acetate NOT be included on the 503A bulk drug substances list ²^3. DSIP is not named in the WADA 2026 Prohibited List ^4.
United States (FDA): Not approved. Drugs@FDA / openFDA returns no application for emideltide or for delta sleep-inducing peptide ^1. The substance was taken to the Pharmacy Compounding Advisory Committee on July 24, 2026 (morning session) for a vote on inclusion on the 503A bulks list ^2, and FDA's briefing document states "FDA is proposing that Emideltide (free base) NOT be included on the 503A Bulks List" and the same for emideltide acetate; footnotes record that both nominations (LDT Health Solutions, Inc. on behalf of International Peptide Society, and Wells Pharmacy Network) were "withdrawn by the nominator" and that FDA elected to proceed with the presentation anyway ^3.
Sport (WADA): Not named. Full-document word searches of the WADA 2026 Prohibited List for "delta sleep", "DSIP" and "emideltide" return nothing, so DSIP is not a named prohibited substance for 2026 ^4. The list's class definitions are open-ended, so athletes should consult their anti-doping organisation rather than treat this as clearance.

Status varies by country and changes over time. How we describe regulatory status.

DSIP compared with related compounds

Compound	Status	Evidence	Human amounts	Half-life
DSIP	Not approved — research use only	B	None established	—
Sleep Research Blend	Not approved — research use only	—	None established	—
Cerebrolysin	Approved outside the US	A	Ex-US label	Not directly measurable (peptide mixture
Selank	Approved outside the US	B	None established	—
Semax	Approved outside the US	B	None established	—
Dihexa	Not approved — research use only	C	None established	—

Frequently asked questions

What doses of DSIP have been studied in humans?

None that establish an amount. DSIP is not approved anywhere and we found no human studies that administered it. Amiravo does not publish community or vendor figures.

Is there an established DSIP cycle length?

No. We found no human studies that report treatment duration for DSIP.

How much bacteriostatic water should be added to a DSIP vial?

There is no compound-specific volume. The diluent volume only sets the concentration: concentration = mass in the vial ÷ volume added (for example, 10 mg in 2 mL gives 5 mg/mL). The calculator on this page shows the arithmetic for any combination.

How many units is a given amount on an insulin syringe?

On a U-100 syringe, 100 units = 1 mL. Units for an amount = amount ÷ (concentration per unit). The calculator converts any amount you enter at the concentration you choose; a unit is a volume mark, not an amount of compound.

Is DSIP FDA-approved?

Not approved — research use only. DSIP (delta sleep-inducing peptide), referred to by FDA as emideltide, has no approved drug application in the United States; Drugs@FDA / openFDA searches return no records ^1. Emideltide-related bulk drug substances were on the agenda of FDA's Pharmacy Compounding Advisory Committee meeting of July 23-24, 2026, where FDA proposed that emideltide (free base) and emideltide acetate NOT be included on the 503A bulk drug substances list ²^3. DSIP is not named in the WADA 2026 Prohibited List ^4.

References

Drugs@FDA application data queried through openFDA for emideltide and delta sleep-inducing peptide (no matching application record returned on 22 October 2026) openFDA / Drugs@FDA. 2026
July 23-24, 2026: Meeting of the Pharmacy Compounding Advisory Committee (agenda, questions and briefing documents) FDA Advisory Committee Calendar. 2026
FDA Briefing Document, Pharmacy Compounding Advisory Committee Meeting, July 23-24, 2026 (covering BPC-157-, KPV-, TB-500-, MOTS-c-, Emideltide-, Epitalon- and Semax-related bulk drug substances) FDA. 2026
International Standard: Prohibited List 2026 World Anti-Doping Agency. 2026
Delta sleep-inducing peptide (DSIP): a still unresolved riddle J Neurochem. 2006
Delta-sleep-inducing peptide (DSIP): an update Peptides. 1986
Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia Eur Neurol. 1987
Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study Neuropsychobiology. 1992
PubChem compound record for delta sleep-inducing peptide (CID 68816; CAS 62568-57-4) PubChem. 2026

Last reviewed October 22, 2026 by the Amiravo editorial team. Editorial policy · Report an error