
This week in peptide research
Every new PubMed record and registered trial naming a compound in the library, linked to the source, labelled by study type and model.
New studies
- OtherhumansWeight-Loss Outcomes After Sleeve Gastrectomy Versus Tirzepatide in a Minority Cohort With Severe Obesity: Results From a Propensity Score Matched Cohort.Clinical obesity · Dec 1, 2026 · PMID 42850698 · Tirzepatide
- OtherKisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis.Cytotechnology · Dec 1, 2026 · PMID 42871171 · Kisspeptin-10
- OtherOral Semaglutide and the Kidney: Promise, Limitations, and the Road Ahead.Diabetes care · Nov 1, 2026 · PMID 42900811 · Semaglutide
- OtherLiraglutide Dose Affordability and Durability in Real-World Obesity Care.Endocrinology, diabetes & metabolism · Nov 1, 2026 · PMID 42867112 · Liraglutide
- OtherRetraction notice to "Corrigendum to "Apelin-13 impedes foam cells formation by activating ClassIIIPI3K/Beclin mediated autophagic pathway"" [Biochem. Biophys. Res. Commun. 575, (2021), 99-100].Biochemical and biophysical research communications · Oct 29, 2026 · PMID 42810896 · Apelin-13
- OtherRetraction notice to "Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway" [Biochem. Biophys. Res. Commun. 466, (2015), 637-643].Biochemical and biophysical research communications · Oct 29, 2026 · PMID 42816239 · Apelin-13
- OtherParasympathetic dysfunction assessed by deep-breathing CVR-R is associated with early discontinuation of oral semaglutide in type 2 diabetes: A multicenter retrospective study.Journal of diabetes investigation · Oct 24, 2026 · PMID 42921716 · Semaglutide
- OtherApelin-13 exerts neuroprotection through activation of APJ/mTORC2 axis in microglia after Intracerebral Hemorrhage in mice.Brain research bulletin · Oct 23, 2026 · PMID 42918587 · Apelin-13
- Case reportSEMAGLUTIDE TREATMENT IN TWO VERY YOUNG CHILDREN WITH SEVERE EARLY-ONSET OBESITY.Hormone research in paediatrics · Oct 23, 2026 · PMID 42912696 · Semaglutide
- OtherButyrate enhances the obesity reduction effect of Semaglutide.Neuroendocrinology · Oct 23, 2026 · PMID 42912707 · Semaglutide
- OtherMots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence.Biochemical pharmacology · Oct 23, 2026 · PMID 42918312 · MOTS-c
- OtherHumanin variants differentially regulate BID fibrilization and suppress BAX- and BID-dependent membrane permeabilization.The Journal of biological chemistry · Oct 23, 2026 · PMID 42918500 · Humanin
- Registered trialhumansPhase 2/Phase 3Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity.McGill University Health Centre/Research Institute of the McGill University Health Centre · Oct 23, 2026 · NCT07891156 · Semaglutide
- Registered trialhumansMetabolic Effects of Switching From Injectable Semaglutide to TirzepatideLMC Diabetes & Endocrinology Ltd. · Oct 22, 2026 · NCT07889453 · Tirzepatide
- Registered trialhumansPhase 3A Clinical Study to Evaluate the Effects of Enicepatide Versus Tirzepatide in Participants With Type 2 Diabetes and Inadequate Blood Sugar Control on Oral Glucose-Lowering MedicationsHoffmann-La Roche · Oct 22, 2026 · NCT07889648 · Tirzepatide
- OtherTransient Adipose Inflammatory Remodeling during High-Dose Semaglutide-Induced Weight Loss and Regain.Endocrinology and metabolism (Seoul, Korea) · Oct 22, 2026 · PMID 42908410 · Semaglutide
- Registered trialhumansEarly Phase 1Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging ClocksFrontiers in Bioscience Research Institute and Aging · Oct 22, 2026 · NCT07888595 · GHK-Cu
- OtherRetatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.The New England journal of medicine · Oct 21, 2026 · PMID 42904878 · Retatrutide
- RCThumansSemaglutide modulates explore/exploit decision-making in major depressive disorder: A randomized clinical trial.Psychological medicine · Oct 21, 2026 · PMID 42904347 · Semaglutide
- OtherPoly(vinyl alcohol) dissolving microneedles for transdermal semaglutide delivery and anti-obesity therapy in rats.International journal of pharmaceutics · Oct 21, 2026 · PMID 42906796 · Semaglutide
- OtherResponse to Comment on Ganeshalingam et al. Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly.Diabetes care · Oct 20, 2026 · PMID 42900014 · Semaglutide
- OtherOral Versus Injectable Incretin-Based Anti-Obesity Therapies: An Integrated Computational and Evidence-Based Comparison of Orforglipron, Semaglutide, and Tirzepatide.Omics : a journal of integrative biology · Oct 20, 2026 · PMID 42902597 · Tirzepatide
- OtherTirzepatide for Obstructive Sleep Apnea: Trial Evidence, Cardiometabolic Effects, and Implications for Cardiovascular Practice.Cardiology in review · Oct 20, 2026 · PMID 42897716 · Tirzepatide
- Registered trialhumansPhase 2Thymalfasin Combined With Chemotherapy and Immunotherapy in TNBC Neoadjuvant TreatmentFudan University · Oct 20, 2026 · NCT07884201 · Thymosin Alpha-1
- OtherGLP-1s and criminality: US trial will test whether semaglutide can fight crime.BMJ (Clinical research ed.) · Oct 20, 2026 · PMID 42901618 · Semaglutide
- OtherSafety outcomes of semaglutide by chronic kidney disease severity in the FLOW trial.Kidney international · Oct 20, 2026 · PMID 42901325 · Semaglutide
- OtherCorrection to 'Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post Hoc Analysis of REDEFINE 1'.Diabetes, obesity & metabolism · Oct 20, 2026 · PMID 42897974 · Cagrilintide
- OtherOccult Abdominal Para-Aortic Ectopic Insulinoma Localized by 18F-NOTA-Exendin-4 PET/CT.Clinical nuclear medicine · Oct 20, 2026 · PMID 42912647 · Exenatide
- Registered trialhumansA Real-world Study of Treatment Retention and Adherence to Secukinumab in Patients With Plaque Psoriasis (PsO) With or Without Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) Co-therapyNovartis Pharmaceuticals · Oct 19, 2026 · NCT07881783 · Liraglutide
- OtherMechanistic benchmarking of SNAC, DDM, and LLC reveals enhancer-dependent pathways for intestinal semaglutide delivery.Journal of controlled release : official journal of the Controlled Release Society · Oct 19, 2026 · PMID 42896658 · Semaglutide
- OtherChanges in Muscle Strength Following Semaglutide Treatment in Adults: A Systematic Review With Meta-Analysis of Handgrip Strength.Diabetes, obesity & metabolism · Oct 19, 2026 · PMID 42897109 · Semaglutide
- OtherReal-World Semaglutide Initiation Behaviours in the United States: Impact on Early Treatment Discontinuation and on 1-Year Persistence.Diabetes, obesity & metabolism · Oct 19, 2026 · PMID 42897121 · Semaglutide
- OtherThe Mitochondrial-Derived Peptide MOTS-c Improves Bioenergetics in Aging-Associated Granulosa Cells and Oocytes.Reproduction & fertility · Oct 19, 2026 · PMID 42895211 · MOTS-c
- Registered trialhumansPhase 3A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 DiabetesEli Lilly and Company · Oct 19, 2026 · NCT07881458 · Tirzepatide
- Registered trialhumansPhase 2Semaglutide for the Treatment of Cannabis Use DisorderMassachusetts General Hospital · Oct 19, 2026 · NCT07879612 · Semaglutide
- Registered trialhumansSemaglutide Health Outcomes and Patient Adherence in AustraliaNovo Nordisk A/S · Oct 19, 2026 · NCT07881770 · Semaglutide
- OtherInterpreting Survodutide Renoprotection in a Hyperfiltration Model.Diabetes, obesity & metabolism · Oct 19, 2026 · PMID 42897119 · Survodutide
- Registered trialhumansNAAI-Personalized Skincare Regimen for Facial Photoaging in WomenMDalgorithms Inc. · Oct 19, 2026 · NCT07879833 · Argireline
- Registered trialhumansPhase 3A Study of EloraTZP in Adult Participants With Obesity Without Type 2 DiabetesEli Lilly and Company · Oct 19, 2026 · NCT07881432 · Tirzepatide
- OtherDiabetic Retinal Disease Onset and Progression During Established Semaglutide or Tirzepatide Treatment: A Retrospective Comparative Cohort Study With a Descriptive Regional Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Review.Cureus · Oct 19, 2026 · PMID 42909983 · Tirzepatide
- OtherReal-world observational study evaluating metabolic and kidney outcomes in patients living with chronic kidney disease and type 2 diabetes mellitus with obesity prescribed tirzepatide.Diabetic medicine : a journal of the British Diabetic Association · Oct 19, 2026 · PMID 42897718 · Tirzepatide
- OtherTirzepatide-Associated Lithium Toxicity: A Case Report.Journal of clinical psychopharmacology · Oct 19, 2026 · PMID 42895194 · Tirzepatide
- OtherImpact of setmelanotide on metabolic syndrome risk in patients with proopiomelanocortin or leptin receptor deficiencies.The Journal of clinical endocrinology and metabolism · Oct 19, 2026 · PMID 42895739 · Setmelanotide
- RCThumansEffects of the GnRH agonist leuprorelin on liver volume in premenopausal women with severe polycystic liver disease.Hepatology communications · Oct 19, 2026 · PMID 42900154 · Leuprolide
Changes to our entries
- Pentadeca arginate (PDA) · Oct 24, 2026
New research reference added: Pentadeca arginate (PDA).
- TB-500 · Oct 24, 2026
Removed a ClinicalTrials.gov record (NCT07487363) that its sponsor describes as an example, not a real study.
- MOTS-c · Oct 24, 2026
Removed a ClinicalTrials.gov record (NCT07505745) that its sponsor describes as an example, not a real study.
- BPC-157 · Oct 24, 2026
Removed a ClinicalTrials.gov record (NCT07437547) that its sponsor describes as an example, not a real study.
- GHK-Cu · Oct 24, 2026
Removed a ClinicalTrials.gov record (NCT07437586) that its sponsor describes as an example, not a real study.
- Tesofensine · Oct 24, 2026
WADA class corrected: tesofensine is listed under S6.B (specified stimulants), not S6.A.
- Apelin-13 · Oct 24, 2026
New research reference added: Apelin-13.
- Thymulin · Oct 24, 2026
New research reference added: Thymulin.
- MariTide (maridebart cafraglutide) · Oct 24, 2026
New research reference added: MariTide (maridebart cafraglutide).
- Ecnoglutide · Oct 24, 2026
New research reference added: Ecnoglutide.
- Matrixyl · Oct 24, 2026
New research reference added: Matrixyl.
- Argireline · Oct 24, 2026
New research reference added: Argireline.
- Adipotide · Oct 24, 2026
New research reference added: Adipotide.
- Triptorelin · Oct 24, 2026
New research reference added: Triptorelin.
- Abaloparatide · Oct 24, 2026
New research reference added: Abaloparatide.
- Leuprolide · Oct 24, 2026
New research reference added: Leuprolide.
- Thymosin beta-4 · Oct 24, 2026
New research reference added: Thymosin beta-4.
- Orforglipron · Oct 24, 2026
New research reference added: Orforglipron.
- hCG (human chorionic gonadotropin) · Oct 24, 2026
New research reference added: hCG (human chorionic gonadotropin).
- Octreotide · Oct 24, 2026
New research reference added: Octreotide.
- Setmelanotide · Oct 24, 2026
New research reference added: Setmelanotide.
- Teduglutide · Oct 24, 2026
New research reference added: Teduglutide.
- Larazotide · Oct 24, 2026
New research reference added: Larazotide.
- Dulaglutide · Oct 24, 2026
New research reference added: Dulaglutide.
- Exenatide · Oct 24, 2026
New research reference added: Exenatide.
- Pramlintide · Oct 24, 2026
New research reference added: Pramlintide.
- Teriparatide · Oct 24, 2026
New research reference added: Teriparatide.
- Vasopressin · Oct 24, 2026
New research reference added: Vasopressin.
- Oxytocin · Oct 23, 2026
Added week-by-week schedules from the FDA label (1 group, 1 arms).
- Retatrutide · Oct 23, 2026
Added week-by-week schedules from registered trials (5 groups, 21 arms).
- Survodutide · Oct 23, 2026
Added week-by-week schedules from registered trials (5 groups, 15 arms).
- Cagrilintide · Oct 23, 2026
Added week-by-week schedules from registered trials (1 group, 5 arms).
- Mazdutide · Oct 23, 2026
Added week-by-week schedules from registered trials (3 groups, 7 arms).
- Eloralintide · Oct 23, 2026
Added week-by-week schedules from registered trials (1 group, 6 arms).
- Amycretin · Oct 23, 2026
Added week-by-week schedules from registered trials (3 groups, 13 arms).
- Pemvidutide · Oct 23, 2026
Added week-by-week schedules from registered trials (1 group, 2 arms).
- VK2735 · Oct 23, 2026
Added week-by-week schedules from registered trials (1 group, 4 arms).
- Tesofensine · Oct 23, 2026
Added week-by-week schedules from registered trials (1 group, 3 arms).
- ARA-290 · Oct 23, 2026
Added week-by-week schedules from registered trials (1 group, 3 arms).
- VIP · Oct 23, 2026
Added week-by-week schedules from registered trials (2 groups, 2 arms).
- PT-141 · Oct 23, 2026
Added week-by-week schedules from the FDA label (1 group, 1 arms).
- Afamelanotide · Oct 23, 2026
Added week-by-week schedules from the FDA label (1 group, 1 arms).
- Tesamorelin · Oct 23, 2026
Added week-by-week schedules from the FDA label (1 group, 2 arms).
- Liraglutide · Oct 23, 2026
Added week-by-week schedules from the FDA label (2 groups, 4 arms).
- Tirzepatide · Oct 23, 2026
Added week-by-week schedules from the FDA label (2 groups, 5 arms).
- Semaglutide · Oct 23, 2026
Added week-by-week schedules from the FDA label (4 groups, 11 arms).
- Tesofensine · Oct 23, 2026
Re-cited the half-life to the population pharmacokinetic study that measured it (Alzheimer patients).
- Mazdutide · Oct 23, 2026
Re-cited the half-life to the phase 1b study that measured it.
- Cagrilintide · Oct 23, 2026
Re-cited the half-life to the phase 1b study that measured it, and noted it was measured alongside semaglutide.
- ARA-290 · Oct 23, 2026
Corrected the phase 2 amounts: no phase 2 trial gave 2 mg per day; the 2 mg amount was intravenous, in a pilot and a healthy-volunteer study.
- Retatrutide · Oct 23, 2026
Corrected the phase 2 treatment duration from 24–48 weeks to 36–48 weeks; 24 weeks was only the primary endpoint of the type 2 diabetes trial.
- Semaglutide · Oct 23, 2026
Corrected which label each amount is cited to: tablet amounts now cite the Rybelsus/Ozempic tablets label and Wegovy amounts the Wegovy label.
Filed automatically from PubMed and ClinicalTrials.gov when a library compound's name appears in the title or abstract; study type and model come from the index record, not from reading the paper. Inclusion is not an endorsement.